送交者: Wood 于 2006-4-11, 15:48:52:
1. Solve the x-ray structures of his receptor in both lidand -free and -bond forms, try to spot differences between the two, if any.
3. Use ESR higher than 100 GHz to identify interactions between pairs of atoms
4. Modified the receptor and / or the ligand and solve more structures.
5. ESR to see the difference
6. Try to make sense between the X-ray structures, ESR spectra and binding affinities.
7. Back to cell biology and animal experiments, he might then find something useful.
Hope this can save his life.