送交者: alabama 于 2012-04-25, 12:02:55:
A 60 year old chemist was admitted two hours after voluntary intake of 600 mg potassium cyanide. Upon admission he was in deep coma and bradypneic but non-cyanotic. Arterial blood gas analysis showed severe lactic acidosis; blood cyanide concentration was well above the lethal level. The patient was intubated and artificially ventilated with highly hyperoxic mixtures. Specific treatment included sodium nitrite and sodium thiosulfate. The patient recovered without sequelae despite excessive methemoglobinemia.
[feihl f et al; schweiz med wochenschr 112 (37): 1280-82 (1982)] **PEER REVIEWED** PubMed Abstract
An 18 year old man ingested 975 to 1,300 mg of potassium cyanide in a suicide attempt. He was treated and survived the poisoning episode, but then had severe parkinsonian syndrome, characterized primarily by akinesia and rigidity. He died 19 months after the drug overdose. At autopsy, major destructive changes were found in the globus pallidus and putamen, whereas the melanin-containing zone of substantia nigra was intact. This is the first clinicopatholic report of parkinsonism as a result of cyanide poisoning.
[uitti rj et al; neurology 35 (6): 921-25 (1985)] **PEER REVIEWED** PubMed Abstract