都是哥哥惹的祸 -- The maternal immune hypothesis



所有跟贴·加跟贴·新语丝读书论坛http://www.xys.org/cgi-bin/mainpage.pl

送交者: Latino2 于 2005-5-11, 14:59:17:

回答: 有不同的汗线 由 xj 于 2005-5-11, 13:42:45:

弗罗依德当初也观察到弟弟中同性恋较多这一现像,但牵强符会的作了错误的解释。

不过这个仍然是假说 - a plauxible hypothesis.

Male sexual orientation influenced by prenatal factors, birth order
A newly published study suggests sexual orientation in males is influenced by prenatal development.

Blanchard, R. (2004). Quantitative and theoretical analyses of the relation between older brother and homosexuality in men. Journal of Theoretical Biology, 230, 173-187.
ABSTRACT

Meta-analysis of aggregate data from 14 samples representing 10,143 male subjects shows that homosexuality in human males is predicted by higher numbers of older brothers, but not by higher numbers of older sisters, younger brothers, or younger sisters. The relation between number of older brothers and sexual orientation holds only for males. This phenomenon has therefore been called the fraternal birth order effect. Research on birth order, birth weight, and sexual orientation suggests that the developmental pathway to homosexuality initiated by older brothers operates during prenatal life. Calculations assuming a causal relation between older brothers and sexual orientation have estimated the proportion of homosexual men who owe their sexual orientation to fraternal birth order at 15 percent in one study and 29 percent in another.

The maternal immune hypothesis proposes that the fraternal birth order effect reflects the progressive immunization of some mothers to male-specific antigens by each succeeding male fetus and the increasing effects of such immunization on sexual differentiation of the brain in each succeeding male fetus. There are at least three possible mechanisms by which the mother's immune response could influence the fetus:
the transfer of anti-male antibodies across the placenta from the maternal into the fetal compartment, the transfer of maternal cytokines across the placenta, and maternal immune reactions affecting the placenta itself. This hypothesis is consistent with recent studies showing that the quantity of fetal cells that enter the maternal circulation is greater than previously thought, and that the number of male-specific proteins encoded by Y-chromosome genes is greater than previously thought.





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