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送交者: qtl 于 2013-06-08, 13:51:13:

回答: 有没有人存下来? 由 方舟子 于 2013-06-08, 13:31:30:

NEWS
Disturbing rumours embroil GSK China

David Cyranoski
06 June 2013
The Chinese blogosphere is afire over a rumour that the head of the Chinese R&D unit for GlaxoSmithKline (GSK) is under investigation for scientific fraud.
The story has circulated widely since it was published anonymously, under the authorship of “formergskemployees”, on a science watchdog website, New Threads, on 31 May.
The anonymous poster alleges that a 2010 paper published in Nature Medicine1 was fraudulent. The paper was authored by Jingwu Zang, senior vice-president of GSK R&D China and an expert in autoimmune disease.
The paper claims to show the crucial role of a certain cell receptor — the interleukin-7 receptor (IL-7R) — in multiple sclerosis (MS) using a mouse model of the disease and blood samples from MS patients.
The allegations in the anonymous post include a claim that data said to describe the effect of blocking the pathogenic IL-7R in patient samples actually used blood samples from healthy subjects and points to a discrepancy on that point between the original laboratory records data and the text in the paper.
Other scientists have tried and failed to replicate the results. One study2 states: “Our results on the therapeutic efficacy of IL-7Rα–blocking antibody in EAE mice are largely consistent with the study by [zang’s group]. Our detailed mechanistic studies, however, have yielded results that are quite different from their findings.” The paper adds: “The conflicting observations … were not likely due to differences in the experimental protocols, because we diligently followed their methods.”
GSK's global external communications director, David Daley, told Nature: “We are carrying out an internal investigation into some alleged issues related to a scientific paper but I don’t have further details at the moment. It wouldn’t be appropriate for us to comment on particular aspects of an investigation while it is ongoing. The integrity of our research is critical to our work and we are doing whatever is required to investigate these matters fully.”
Nature Medicine's editor-in-chief Juan Carlos Lopez says: “There is an ongoing internal investigation at GSK. We expect to receive the results within the next few days.” Lopez denies rumours that Nature Medicine had sent staff to be part of the investigation.
The paper’s list of author contributions says that Zang “designed and discussed the study”, “contributed to the writing of the paper” and “supervised the project” but was not involved in conducting the actual experimental procedures.
The post on New Threads says that Zang has left the company. A representative at the Shanghai-based R&D research unit confirmed that Zang was on “temporarily on leave”. Attempts to reach him through his personal assistant were unsuccessful, and e-mails to his GSK account bounced back.
New Threads is a website famous for its role in debunking fraudulent scientists (see ' A hammer blow to national ethics ' and ' Courage for sound science wins John Maddox Prize '). Shi-Min Fang, who runs the New Threads website, says he knows little about the case, other than what was alleged in the anonymous post. “Several days ago, a former employee of GSK sent me an article disclosing the results of the investigation, and I posted it on our New Threads website on 31 May.”
GSK entered China promising to change the way pharmaceutical research and development was done there. It planned to create a massive presence — with 1,000 employees — when it opened its Shanghai doors in 2007. Whereas most other Western pharmaceutical companies made smaller investments in China and outsourced only certain stages of preclinical development to Chinese units, GSK made its Chinese unit wholly autonomous and gave it full responsibility for developing drugs, from basic research to clinical trials, for neurodegenerative disease (see ' Pharmaceutical futures: Made in China? ').
References

1.Liu, X. et al. Nature Med. http://dx.doi.org/10.1038/nm.2077 (2010).
2.Lee, F.-L. et al. Sci. Transl. Med. http://dx.doi.org/10.1126/scitranslmed.3002400 (2011).
Related links

Courage for sound science wins John Maddox prize 2012-Nov-07
A hammer blow to national ethics 2010-Oct-20
Pharmaceutical futures: Made in China? 2008-Oct-29
Related external links

Journal title:Nature NewsDate published:(06 June 2013)doi:10.1038/nature.2013.13154




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