送交者: slk 于 2005-9-14, 16:02:19:
As we all know the winning of R01 is national wide recognization.I think his scientific achievement should be respected.
http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6698512&p_grant_num=5R01DK053063-05&p_query=&ticket=16724710&p_audit_session_id=78530045&p_keywords=
Abstract
Grant Number: 5R01DK053063-05
PI Name: XIAO, CHUAN-GUO
PI Email: chuanguo.xiao@med.nyu.edu
PI Title:
Project Title: SKIN-CNS-BLADDER REFLEX ARC FOR MICTURITION AFTER SCI
Abstract: The neurological bladder caused by spinal cord injury (SCI) presents a significant medical and social problem. There is no satisfactory treatment yet. Supported by the Paralyzed Veterans of America and NIH, a new reflex pathway, "Skin-CNS-Bladder" for controlled micturition after SCI has been successfully established in rat, cat and canine models. Preliminary clinical application of 14 SCI patients also provided very promising results. The study proposed here is to transfer the Skin-CNS-Bladder reflex functions. The ventral root (VR) of a lumbar nerve (L5) below the spinal cord lesion will be anastomosed to the sacral VR (S2 and/or S3) which innervate the bladder, while leaving the intact L5 dorsal root (DR) as a started of micturition. After the axonal regeneration, controllable voiding would be initiated by scratching the L4 dermatome. Effect of the new reflex pathway on bladder function will be evaluated by means of electrophysiology and urodynamics. Its effect on bowel and sexual functions will also be studied. The procedure may revolutionize the treatment of neurogenic bladder after SCI, It requires relatively minor surgery on 2 paralyzed nerves. It does not involve implantation of electrodes or other devices but provides unique voluntary control of bladder emptying. Scientifically, the study will further prove the new concept derived from the unique somatic-autonomic reflex that the impulses delivered from the efferent neurons of a somatic reflex arc may be transferred to initiate response of an autonomic effector. This new concept may be widely useful, not only for neurogenic bladder, but also for other problems caused by the spinal cord injury or diseases.
Thesaurus Terms:
electrophysiology, human therapy evaluation, neurogenic urinary bladder disorder, neuroregulation, neurosurgery, somatic reflex, spinal cord injury, urination
central nervous system, clinical trial, functional ability, outcomes research, quality of life, skin, urinary electronic stimulator
clinical research, human subject
Institution: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
550 1ST AVE
NEW YORK, NY 10016
Fiscal Year: 2004
Department: UROLOGY
Project Start: 30-SEP-1999
Project End: 31-DEC-2005
ICD: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
IRG: ZRG1