老鼠实验表明,咖哩粉中的姜黄素能有效的抑止乳腺癌扩张



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送交者: Latino2 于 2005-10-17, 19:25:29:

咖哩粉中大量的姜黄素能有效的抑止乳腺癌扩张,从而进而抑制乳癌向肺癌转移。

研究人员把60只患乳腺癌的老鼠分成喂咖哩的和不喂的, 结果喂咖哩的老鼠乳腺癌受到明显抑止。

你们秦人笑话人家老印一股咖哩味。
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Early Study Shows Spice Stunts Deadly Spread To Lungs

HOUSTON - Curcumin, the main ingredient of turmeric and the compound that gives curry its mustard-yellow color, inhibits metastasis to the lungs of mice with breast cancer, report researchers at The University of Texas M. D. Anderson Cancer Center.

The study, to be published in the Oct. 15 issue of the journal Clinical Cancer Research, reports that the spice appears to shut down a protein active in the spread of breast cancer to a major target for metastasis.

Though the study results are early, researchers found that the nontoxic natural substance not only repelled progression of the disease to the lungs, but also appeared to reverse the effects of paclitaxel (TaxolTM), a commonly prescribed chemotherapy for breast cancer that may trigger spread of the disease with use over a long period of time.

Because Taxol is so toxic, it activates a protein that produces an inflammatory response that induces metastasis. Curcumin suppresses this response, making it impossible for the cancer to spread. In fact, researchers found that adding curcumin to Taxol actually enhances its effect. Curcumin breaks down the dose, making the therapy less toxic and just as powerful while delivering the same level of efficacy.

Researchers studied 60 mice with breast cancer, which were randomly assigned to one of four groups: control group, Taxol only, curcumin only and the combination of Taxol and curcumin. After the tumors grew to 10 mm (about the size of a pea), they were surgically removed, and the mice were fed a powdered curcumin diet.

Microscopic metastasis, or metastasis that is visible only when using a microscope, was found in the lungs of 28 percent of mice treated with the combination of curcumin and Taxol, and there was no macroscopic disease present. The micrometastases present consisted of only a few cells, suggesting that the combination inhibited the growth of breast cancer tumor cells that were in the lung before the tumors were removed.

In a previous study published in the Aug. 15 issue of the journal Cancer, M. D. Anderson researchers found that when the nuclear factor-kappa B (NF-kB) (a powerful protein known to promote the inflammatory response necessary to cause breast cancer to spread) is shut down, cancer strains are unable to grow and cells are pushed to commit suicide.
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The study was funded by the United States Department of Defense. Co-authors include Shishir Shishodia, Ph.D.; Yasunari Takada, Ph.D.; Sanjeev Banerjee, Ph.D.; Robert A. Newman, Ph.D.; Carlos Bueso-Ramos, M.D., Ph.D.; and Janet E. Price, Ph.D.

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This story has been adapted from a news release issued by University of Texas M. D. Anderson Cancer Center




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