◇◇新语丝(www.xys.org)(xys5.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)◇◇ Beaumont医院“肖氏手术”临床试验一年结果原始数据资料 作者:羽矢 有网友刚索取到一份文档(网上未见公布),包含Beaumont一年结果原始数据资 料。文件日期是2009年10月1日,应该是Peters在ICS 2009会议上的 presentation。 de Groat曾参加这次会议: http://www.urotoday.com/component/jentlacontent/1451-ics-2009-session-highlights-3050/32064-ics-2009-state-of-the-art-lecture-bladder-reinnervation-can-new-nerves-improve-the-function-of-the-neurogenic-bladder-session-highlights-2224980.html http://www.icsoffice.org/Documents/DocumentsDownload.aspx?DocumentID=535 肖也参加了,称“最近的会上,在美国做的9个病人9个大便正常,9个能自己拉 尿。” http://www.starlakeporch.net/bbs/read.php?1,53703,53703#msg-53703 该文档中的“Voiding and Urodynamic Data”表与Beaumont的1年结果论文 Table 2中的Reflex一列,5、6号患者数据不一致。应该是笔误。 4、7号患者用右侧神经作为donor。肖曾辩解"左脚,还是右脚?鹿,还是马?", 称“肖氏反射弧手术基本只用左侧的神经”: http://blog.sciencenet.cn/home.php?mod=space&uid=385748&do=blog&id=322885 1、5、7号患者用了donor root from above the lesion,而肖一直是"用废弃的 神经"的说法。 最令人吃惊的是文档中“Global Response”表的结果。论文中没有提到该结果。 自诉Markedly better的只有两人。一个是#1号患者(“井冈山女孩”Rebecca Quass)三项 Markedly better,该患者没做过封闭术,应该是封闭术的效果;另一个是#2号患者,大便 Markedly better、但不愿再做一次手术。另外,与1年论文对照,自诉小便改善的4名患者, 膀胱容量增、减各2名。 患者自诉小便改善4/9。作为肖氏手术“副产品”的大便改善是6/9。NYU的Dr. Kelly曾猜测是停用肌肉麻痹药的效果。 http://www.modernmedicine.com/modernmedicine/Urinary+Incontinence%2FOveractive+Bladder/Procedure-gives-voiding-control-to-SCI-patients/ArticleStandard/Article/detail/188392 "We postulate two possible reasons for the improved bowel function," observed Dr. Kelly. "It may be secondary to discontinuation of anticholinergic medication or reinnervation of the large bowel parasympathetic ganglion." 不知道论文审稿人和NIH是否知晓这个Global Response结果。 此表被歪曲为: It changed their quality of life enough to the point at which seven of nine would undergo the procedure again. http://www.springerlink.com/content/t26145l041079l56/fulltext.html 一年结果摘要称: 9/9 of patients demonstrated a reflex bladder contraction and/or the ability to initiate voiding by one year. Improvement in bowel function was reported on twelve month global assessment scores in 6 of 9 patients. http://medicalconference.spinabifidaassociation.org/atf/cf/%7B10221c89-6b69-45bd-81bf-3194b0be6fa5%7D/UROL27.PDF 两年结果摘要称: Quality of life was improved in 6/9 (66%) of patients and worse in 1 (foot drop) 不知道三年GRA结果中的“improved”掺水到什么程度: [] Bowels improved 5/7 on GRA [] Bladder improved 4/7 on GRA [] 6/7 would undergo surgery again 失访的两名,应该是2和7号患者: http://www.xys.org/forum/db/9/64/144.html 不是4,因为1 year: 7/9 would re-do the surgery, 3 years: 6/7 论文和该文件中的表合在一起了: http://xysblogs.org/wp-content/blogs/107/uploads/tab12a.gif (XYS20110928) ◇◇新语丝(www.xys.org)(xys5.dxiong.com)(www.xinyusi.info)(xys2.dropin.org)◇◇