◇◇新语丝(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)◇◇ 请纽约大学肖传国给美国纳税人一个满意的解释 作者:blackbox   请纽约大学肖传国读了此文后,尽快给所有美国纳税人一个满意的解释答复。 假如你不回答,美国纳税人有权直接质问提供你研究基金的美国国家卫生研究院 (NIH),要求纳税人居住州的联邦议员提供协助,以获得满意的答复。   通过检索美国政府NIH的网站,很容易查到纽约大学肖传国于1999年获得一 笔较大的研究基金,编号Grant Number: 5R01DK053063-05,(检索其它网址显 示基金额高达二百四十万美元),项目名称Project Title: SKIN-CNS-BLADDER REFLEX ARC FOR MICTURITION AFTER SCI(spinal cord injury )。项目年限: 30-SEP-1999 至 31-DEC-2006。摘要介绍并且显示,此研究项目是以人体为研究 对象的临床试验,涉及病人神经外科手术治疗后的效果评估。那么,从项目开始 时间 1999年9月到今天2006年8月10日,7年的时间,肖传国这笔国家基金已经接 近耗尽。美国纳税人想知道的就是,有无与此项目有关的文章公开发表疗效评估 结果?   本人用美国国家医学图书馆提供的pubmed检索系统,输入关键词‘Xiao CG’,检索2006年及之前肖传国发表的论文,检索到肖传国一共发表了专业论文 14篇,去掉1999年9月以前4篇,一共10篇发表在他获得联邦基金 NIH R01DK053063 期间。这10篇文章包括了5篇用英语书写,4篇中文及1篇德文书写。 5篇用中文及德文书写不予评论,因为绝大多数的美国纳税人看不懂。   让我们看看5篇英文论文里有无与此联邦基金R01DK053063有关的疗效评估结 果发表。本人阅读的其中4篇全文(暂无法获得1篇刚发表于2006年8月 (Chin J Traumatol)文章),仅1篇提到获得此联邦基金R01DK053063的支持,细读此文, 发现该发表在2006年Eurpean Urology的文章为综述Review,引用了肖传国本人 以往发表论文的结果数据,没有任何新的未曾发表的结果。但是其中引用的一篇 摘要(abstract)引起本人的兴趣,其发表于2005年J Urol上的摘要题目为 ‘CREATION OF A SOMATIC-AUTONOMIC REFLEX PATHWAY FOR TREATMENT OF NEUROGENIC BLADDER IN PATIENTS WITH SPINAL CORD INJURY: PRELIMINARY RESULTS OF FIRST 2 USA PATIENTS ’ by Christopher E Kelly, Chuan-Guo Xiao, Howard Weiner, Aleksandar Beric, Victor W Nitti, Herbert Lepor, New York, NY。摘要无说明是否由联邦基金R01DK053063资助,在此假设是的话, 难道2百多万都花在全美国的首2例病人的术后疗效评估?注意我指的是疗效评估, 根据了解,通常,联邦研究基金R01不资助研究对象病人的手术及住院费用。到 底肖传国的R01项目申请书里预定的研究对象病人的数目(sample size)是多少? 这些病人的手术是在中国做还是美国做?假如是在中国做,NIH采取了什么措施 来保证研究项目的质量以及维护研究对象病人的安全与利益?   最后,再次要求,请用了7年的时间花了美国纳税人二百四十万美元的纽约 大学肖传国交出以英文书写的原创报告(original report)。 附录: (1) 肖传国NIH研究基金(R01DK053063) Grant Number: 5R01DK053063-05 PI Name: XIAO, CHUAN-GUO PI Email: mailto:chuanguo.xiao@med.nyu.edu PI Title: Project Title: SKIN-CNS-BLADDER REFLEX ARC FOR MICTURITION AFTER SCI Institution: NEW YORK UNIVERSITY SCHOOL OF MEDICINE NEW YORK, NY 10016 Fiscal Year: 2004 Department: UROLOGY Project Start: 30-SEP-1999 Project End: 31-DEC-2006 ICD: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES IRG: ZRG1 Source: http://crisp.cit.nih.gov/crisp/CRISP_LIB.getdoc?textkey=6698512&p_gran t_num=5R01DK053063-05&p_query=&ticket=23631638&p_audit_session_id=1157 81711&p_keywords= Source: NIH (NIDDK) R01 DK 53063 01A2 (Human study) Title: Skin CNS Bladder reflex pathway for micturition. Amount: $2,423,082 (direct costs) Period: 9/1999 9/2004 Source: http://www.xys.org/xys/ebooks/others/science/dajia6/xiaochuanguo11.txt (2) PUBMED检索到的2006年8月及之前肖传国发表的论文, 项目基金 Published papers after 1999 (total=10 including English written 5 , Chinese written 4 and German 1) English Written (total=5) 1: Li WC, Xiao CG. Anorectal functions in patients with lumbosacral spinal cord injury. Chin J Traumatol. 2006 Aug;9(4):217-22. PMID: 16848993 [pubmed - in process] Funding agent: Full-text paper not available on Web 2: Xiao CG. Reinnervation for neurogenic bladder: historic review and introduction of a somatic-autonomic reflex pathway procedure for patients with spinal cord injury or spina bifida. Eur Urol. 2006 Jan;49(1):22-8; discussion 28-9. Epub 2005 Nov 2. Review. PMID: 16314037 [pubmed - indexed for medline] ‘Supported by grants from: The National Key Basic Research Program of China (2003CB515300); The Ministry of Public Health of China (Major Clinical Trial Grant); Natural Science Foundation of China (NSFC 39925033); and NIH (R01 DK44877 and R01 DK53063).’ Funding agent: including NIH R01DK053063 3: Xiao CG, Du MX, Li B, Liu Z, Chen M, Chen ZH, Cheng P, Xue XN, Shapiro E, Lepor H. An artificial somatic-autonomic reflex pathway procedure for bladder control in children with spina bifida. J Urol. 2005 Jun;173(6):2112-6. PMID: 15879861 [pubmed - indexed for medline] ‘Supported by Grant 2003CB515300 from National Key Basic Research Program of China, major clinical trial grant from Ministry of Public Health of China and Natural Science Foundation of China Grant 39925033.’ Funding agent: none NIH 4: Dai CF, Xiao CG. Electrophysiological monitoring and identification of neural roots during somatic-autonomic reflex pathway procedure for neurogenic bladder. Chin J Traumatol. 2005 Apr;8(2):74-6. PMID: 15769303 [pubmed - indexed for medline] Funding agent: no listed 5: Xiao CG, Du MX, Dai C, Li B, Nitti VW, de Groat WC. An artificial somatic-central nervous system-autonomic reflex pathway for controllable micturition after spinal cord injury: preliminary results in 15 patients. J Urol. 2003 Oct;170(4 Pt 1):1237-41. PMID: 14501733 [pubmed - indexed for medline] ‘Supported by Grants NSFC39740037, 39830370 and 39925033 from the National Scientific Foundation of China, and the Major Clinical Trial Grant of Health Ministry of China (1997).’ Funding agent: none NIH Non-English written (total=5) 6: Liu Z, Liu CJ, Hu XW, Du MX, Xiao CG. [an electrophysiological study on the artificial somato-autonomic pathway for inducing voiding] Zhonghua Yi Xue Za Zhi. 2005 May 25;85(19):1315-8. Chinese. PMID: 16029629 [pubmed - indexed for medline] Funding agent: not found (Chinese written) 7: Sievert KD, Xiao CG, Hennenlotter J, Seibold J, Merseburger AS, Kaminskie J, Nagele U, Stenzl A. [voluntary micturition after intradural nerve anastomosis] Urologe A. 2005 Jul;44(7):756-61. Review. German. PMID: 15959611 [pubmed - indexed for medline] Funding agent: not found (German written ) 8: Pang ZL, Xiao CG, Zeng PQ, Lu GC, Zhang QJ. [ureteroscopic holmium: yag laser lithotripsy for managing urinary tract calculi] Zhonghua Wai Ke Za Zhi. 2004 Jan 22;42(2):92-3. Chinese. PMID: 15009989 [pubmed - indexed for medline] Funding agent: not found (Chinese written) 9: Dong CJ, Zhang WX, Xiao CG. [making the scoring card based on pediatric critical illness score] Zhonghua Er Ke Za Zhi. 2003 Jan;41(1):63. Chinese. No abstract available. PMID: 14761338 [pubmed - indexed for medline] Funding agent: not found (Chinese written) 10: Chen ZH, Zhao J, Wu JM, Xiao CG. [the application of complexed psa and its relative indexes in the diagnosis of prostate cancer] Zhonghua Nan Ke Xue. 2003 Feb;9(1):36-9. Chinese. PMID: 12680329 [pubmed - indexed for medline] Funding agent: not found (Chinese written) Published papers in or before 1999 (Total=4) 11: Xiao CG, de Groat WC, Godec CJ, Dai C, Xiao Q. "Skin-CNS-bladder" reflex pathway for micturition after spinal cord injury and its underlying mechanisms. J Urol. 1999 Sep;162(3 Pt 1):936-42. PMID: 10458412 [pubmed - indexed for medline] ‘Supported by grant R01 DK 44877-01 from the Department of Health and Human Services and a grant from the Spinal Cord Research Foundation, Paralyzed Veterans of America.’ Funding agent: non- NIH R01DK053063 12: Xiao CG, Godec CJ. A possible new reflex pathway for micturition after spinal cord injury. Paraplegia. 1994 May;32(5):300-7. PMID: 8058346 [pubmed - indexed for medline] 13: Xiao CG, Xiong XL. Effect of trace elements on the kinetics of calcium oxalate crystallization--research on urolithiatic inhibitors. J Tongji Med Univ. 1986;6(2):100-3. No abstract available. PMID: 3746976 [pubmed - indexed for medline] 14: Lu GC, Xiong XL, Shao MZ, Zhang RQ, Zhang QJ, Chen XC, Zeng FQ, Xiao CG. The pathogenesis of chyluria: retroperitoneal lymphangiectasis. Acta Acad Med Wuhan. 1983;3(4):219-22. No abstract available. PMID: 6358980 [pubmed - indexed for medline] Recent published abstracts (Selected): 15: Christopher E Kelly, Chuan-Guo Xiao, Howard Weiner, Aleksandar Beric, Victor W Nitti, Herbert Lepor, New York, NY . Creation of a somatic-autonomic reflex pathway for treatment of neurogenic bladder in patients with spinal cord injury: preliminary results of the first 2 USA Patients. J Urol 2005;173:1132A. (3) 美国国家卫生研究院(NIDDK)联系人 Griffin P. Rodgers, M.D., M.A.C.P. Acting Director National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health (301) 496-5741 rodgersg@extra.niddk.nih.gov Elizabeth Singer Director (301) 496-3583 singerb@extra.niddk.nih.gov Office of Communications and Public Liaison (NIDDK OCPL) National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Source: http://www.niddk.nih.gov/welcome/org/tables/director_table.htm#EO (XYS20060811) ◇◇新语丝(www.xys.org)(xys.dxiong.com)(xys.3322.org)(xys.xlogit.com)◇◇