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徐荣祥的美宝湿润烧伤膏(MEBO)的临床试验结果

送交者: Yush

新加坡：MEBO与常规疗法具有类似效果，个别方面稍好，不是美宝所声称的治疗
所有烧伤的万能药。

香港：与另两种湿性疗法相比，未显示出美宝所声称的统计意义上的医学优势，
不适合深度烧伤治疗。

黎巴嫩：效果好。

美国：未能在http://clinicaltrials.gov查到美宝所声称的临床试验。

http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_u
ids=10748957&dopt=AbstractPlus
Ann Acad Med Singapore. 2000 Jan;29(1):7-10.
The role of alternative therapy in the management of partial thickness 
burns of the face--experience with the use of moist exposed burn 
ointment (MEBO) compared with silver sulphadiazine.
Ang ES, Lee ST, Gan CS, See P, Chan YH, Ng LH, Machin D.
Department of Plastic Surgery, Singapore General Hospital, Singapore.

RESULTS: In patients with facial burns, MEBO was similar to silver 
sulphadiazine therapy with respect to rate of wound healing. Minimal 
slough was present over the wounds in MEBO-treated wounds resulting in 
clearer assessment of healing progression. CONCLUSIONS: Advantages of 
MEBO as compared to silver sulphadiazine in the management of partial 
thickness burns of the face include convenient change of dressing and 
easier assessment of healing progression. This suggests that MEBO is a 
useful alternative therapy for partial thickness burns of the face.
----------------
http://www.chinaburn.org/rac/pdf/08.pdf
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_u
ids=11549952&dopt=AbstractPlus
MedGenMed. 2001 Mar 6;3(2):3.
Evaluating the role of alternative therapy in burn wound management: 
randomized trial comparing moist exposed burn ointment with 
conventional methods in the management of patients with second-degree 
burns.
Ang ES, Lee ST, Gan CS, See PG, Chan YH, Ng LH, Machin D.
Singapore General Hospital, Department of Plastic Surger, Singapore 
General Hospital, Singapore. Erik_Ang@Hotmail.com

OBJECTIVE: Our study was conducted to compare MEBO with conventional 
management (C) with respect to the rate of wound healing, 
antibacterial and analgesic effect, and hospital costs. ...CONCLUSIONS: 
MEBO is as effective as conventional management but is not the panacea 
for all burn wounds. The use of MEBO eases the management of face and 
neck burns and facilitates early institution of occupational therapy 
in hand burns. It confers better pain relief such that fewer opiates 
are used during the first 5 days after burn injury.

DISCUSSION
...From the results of this prospective RCT, we concludethat MEBO is 
as effective as the conventional approach in the management of 
second-degree burns, though it is not the panacea for all burn wounds 
as claimed....
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http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_u
ids=14501397&dopt=AbstractPlus
J Burn Care Rehabil. 2003 Sep-Oct;24(5):289-96.
Pain control in a randomized, controlled, clinical trial comparing 
moist exposed burn ointment and conventional methods in patients with 
partial-thickness burns.
Ang E, Lee ST, Gan CS, Chan YH, Cheung YB, Machin D.
Singapore National Burn Center, Department of Plastic Surgery, 
Singapore.

...There was little evidence to suggest a difference in pain levels by 
treatment group with the exception of the postdressing pain levels in 
the first week when those receiving MEBO had a mean level of 0.7 cm 
(95% confidence interval, 0.2 to 1.1) lower than those on conventional 
therapy. MEBO appeared to bring greater pain relief for the 
postdressing assessment during the first week after burns. This 
initial relief, together with comparable pain levels experienced on 
other occasions, indicates that MEBO could be an alternative to 
conventional burns management.
----------------
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_u
ids=15879746&dopt=AbstractPlus
J Burn Care Rehabil. 2005 May-Jun;26(3):247-51.
Efficacy of moist exposed burn ointment on burns.
Zhang HQ, Yip TP, Hui I, Lai V, Wong A.
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong.

...although MEBO had a better wound healing rate than the dry exposure 
treatment, it did not show the medical advantage statistically, as has 
been claimed, over the other two treatments (P > .05), either in terms 
of wound healing rate or bacterial control. We conclude that the MEBO 
is not suitable for deep burn wound treatment, particularly when 
infection is a concern.

(XYS20070823)

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