送交者: xj 于 2005-10-05, 17:00:01:
everybody should be aware of.
Every year in the US, almost 200,000 new breast cancer cases based on American Cancer society.
1 in 225 of developing breast cancer for women younger than 39 years, and 1 in 24 for women aged 40-59, and continuously increase with age.
Overally, 1 in 8 women may develop breast cancer in their lifetime.
with earlier detection, the five year survival is above 90%
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The risk factors:
highest (relative risk >4):
Advanced age
Western people
high premenopausal blood insulinlike growth factor 1 (IGF 1)
high postmenopausal estrogen level
mother or sister with breast cancer
Middle (RR 2~4):
high socioeconomic status
age at first full-term pregnancy older than 30 (!)
history of breast cancer
first-degree relative with breast cancer
history of benign proliferative lession in breast
SOme risk (RR 1.1 ~2)
nulliparity
early menarche (age 55y)
postmenopausal obesity
high fat diet
...
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Pretective factors:
age at first period older than 15 y
breast feeding for longer than 1 y
monounsaturated fat diet
physical activity
premenopausal obesity (!)
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In sum, gene is the most important factor, and chance is a bigger factor than anything else.
Anybody has BRCA1 or BRCA2 gene mutation will significantly increase her chance of breast cancer.
Men can have breast cancer too.